KPV

Also known as: Lysine-Proline-Valine, Lys-Pro-Val, alpha-MSH (11-13), alpha-MSH C-terminal tripeptide

Anti-inflammatory tripeptide from alpha-MSH that lowers TNF-alpha and IL-1beta without causing pigmentation. Useful for gut inflammation (selective uptake in the inflamed colon) and skin. Dosed SubQ, oral, or topical.

Pharmacokinetics

Research only · no verified human PK. The values below are class estimates, not measured data, and this peptide is excluded from the Lab serum-level simulator.

Half-life: 30 min
Time to peak: 15 min
Bioavailability: 70%
Dosing interval: 24h

Administration

Primary routes: SubQ, Oral, Topical
Category: Healing & Repair

Safety Flags

High immunogenicity
Contraindicated in cancer history

Storage

· Requires refrigeration (2–8°C)
· Temperature sensitive — minimise room-temp exposure

Used in 4 outcome protocols

Simulate KPV

Pinned.life runs a 1-compartment Bateman pharmacokinetic simulation against 38 peptides in real time. Build a stack, see serum-level curves, get warned about peak overlaps and drug-peptide interactions.

Open the Lab →How the PK engine works