MK-677
Also known as: Ibutamoren, Ibutamoren Mesylate, MK-0677, L-163,191
Orally active ghrelin-receptor agonist that raises GH and IGF-1 while preserving the natural feedback axis. Its strongest effect is on deep slow-wave sleep. Note: increases appetite and can affect insulin sensitivity.
Pharmacokinetics
- Half-life
- 1 day
- Time to peak
- 2 hours
- Bioavailability
- 70%
- Onset
- 1 hours
- Dosing interval
- 24h
Administration
- Primary routes
- Oral
- Category
- Growth Hormone Secretagogues
Safety Flags
- Contraindicated in cancer history
Storage
- · Room temperature stable
Used in 2 outcome protocols
- Muscle GrowthPrimary
Optimize muscle protein synthesis and growth hormone release for enhanced muscle development
Safe default: 10mg · daily · Oral
- Sleep QualityPrimary
Improve sleep architecture and quality of rest
Safe default: 10mg · daily · Oral
Simulate MK-677
Pinned.life runs a 1-compartment Bateman pharmacokinetic simulation against 38 peptides in real time. Build a stack, see serum-level curves, get warned about peak overlaps and drug-peptide interactions.