MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA-c, Mitochondrial-derived peptide, Mitokine
Mitochondrial-derived exercise-mimetic peptide that activates AMPK to improve glucose uptake, fat oxidation, and insulin sensitivity. Requires a washout after extended continuous use.
Pharmacokinetics
- Half-life
- 1.5 hours
- Time to peak
- 30 min
- Bioavailability
- 70%
- Onset
- 1 hours
- Dosing interval
- 120h
Administration
- Primary routes
- SubQ
- Category
- Metabolic
Safety Flags
- High immunogenicity
- Contraindicated in cancer history
Storage
- · Requires freezing
- · Temperature sensitive — minimise room-temp exposure
Used in 5 outcome protocols
- Fat Loss (Lipolysis)
Accelerate fat metabolism and lipolysis without affecting growth hormone levels
Safe default: 5mg · every 5 days · SubQ
- Endurance/Stamina
Improve metabolic efficiency and exercise capacity through mitochondrial optimization
Safe default: 5mg · every 5 days · SubQ
- Mitochondrial FunctionPrimary
Enhance mitochondrial efficiency and reduce oxidative stress
Safe default: 5mg · every 5 days · SubQ
- Blood Sugar
Regulate blood glucose levels and improve glycemic control
Safe default: 5mg · every 5 days · SubQ
- Insulin SensitivityPrimary
Improve cellular response to insulin and metabolic health
Safe default: 5mg · every 5 days · SubQ
Simulate MOTS-c
Pinned.life runs a 1-compartment Bateman pharmacokinetic simulation against 38 peptides in real time. Build a stack, see serum-level curves, get warned about peak overlaps and drug-peptide interactions.